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> My wife has ovarian cancer and it is not responding to chemotherapy, we
> need
> suggestions.  Briefly: She had an operation 1/4/95, had a complete
> hysterectomy, had a
> tumor removed that included removing a small portion of bowel.  Her cancer
> was
> determined to be stage 3.  She was immediately put on a chemotherapy
> treatment of
> Cytoxin and Cisplatin administered monthly.  Her CA-125 dropped into the
> 80′s, but went
> up slightly in May and did not go down in June.  Her July Chemotherapy was
> changed to
> Cisplatin and Paclitaxel.  In Aug. her CA-125 spiked to 872 and a tumor
> was detected
> during a pelvic exam at the end of August.  We are now awaiting a CAT scan
> to
> determine the tumor size.
>    I have heard that Etoposide and Ifosfamide are the next direction
> to go?  I am
> looking for any help and suggestions regarding this or any other possible
> solutions.  
>    Thanks in advance.

>                    Tom Piggins    

Tom,

The alternatives are 1. Investigational drugs. 2.A trial of another
regimen such as etoposide and Ifosfamide or any of several other
agents or 4. Send a sample of the cancer for chemosensitivity tests.
These tests are reasonable good at finding what will not work.
Bill

There is now an Ovarian Problems Discussion Group.  This file will tell
you about the list, how to subscribe, and how to contact a real human
being if you are having problems.

This list is provided to support people who wish to discuss Ovarian Cancer,
and other Ovarian disorders (such as Ovarian cysts).  Ovarian cancer will
be the primary focus of the list.  This list is not to be used for
discussing other issues such as reproductive/fertility problems.

Ovarian cancer strikes tens of thousands of women each year, killing
thousands of them. Because of the difficulty of early detection, Ovarian
cancer is unnecessarily fatal to a great percentage of women who are
diagnosed.

The list is an unmoderated discussion list for patients, family, friends,
researchers, and physicians.  It is free to use.  It includes
patient experiences, psychosocial issues, new research, clinical trials,
and discussions of treatment alternatives.  This list is not associated
with any company or group and is run entirely by volunteers.  Please
distribute this announcement wherever you think it will help, as long as
it stays intact.  Only subscribers will be allowed to post messages to
the Ovarian list, which is to reduce the chance of unrelated mail appearing
on the list.

To SUBSCRIBE to the Ovarian list:
=================================

1) Send electronic mail to this email address:

Lists…@sjuvm.stjohns.edu

2)  Leave the Subject line blank or enter a single character if your
    email program requires something there.

3) Place the following message in the body of the mail:

subscribe ovarian First-name Last-name

For example, to subscribe myself to the list, I would send this message:

subscribe ovarian Kevin J. Sinclair

To UNSUBSCRIBE from the Ovarian List:
=====================================

Send an email to the listserv address with a blank subject line and
the message:

unsubscribe ovarian

(make sure you send this from the account from which your originally
subscribed, if you have more than one email address).

You may change to a digest format, after you subscribe, which means you
would get only 1 (large) message per day.  Full details on this and other
features such as access to archives and other functions of the Ovarian
list will be sent with the acknowledgement of your subscription.

If you are inclined, please send a message to the list to introduce
yourself, after your subscription starts.  This is not required; but it
will make it easier for you to meet people.  After you subscribe, you
will automatically get instructions sent to you via email on how to send
a message, and how to change your subscription options.

If you have ANY problems subscribing or have any questions, you can write
to a human being at:

ovarian-requ…@sjuvm.stjohns.edu

Thank you.

                                                     Last updated 09/11/95