Recently I heard about some new treatment for people with
bone methastases.
I will try to describe it.
The first step is to take bone marrow of the patient.
Then a suspension of very small plastic globulus is added
to the bone marrow. These globulus are coated with monoclonal
antibodies. They also contain iron molecules.
What happens is that they will surround the cancer cells in
the solution. Then a strong magnetic field is applied to the
solution so that the cancer cells are pulled out of the solution.
In this way it is possible to obtain a very good
separation between cancer and normal cells. It should be
possible to remove 1 cancer cell from 1.000.000 normal cells.
After intensive chemotherapy the patients own (filtered) bone
marrow can be put back.
My question is: has anyone heard of this treatment, has
experience with this treatment or knows where it is used ?
Thanks,
Hans Arts
han…@euronet.nl
In article <3mcvkn$…@news.euro.net>, Hans Arts <han…@euronet.nl> wrote:
> Recently I heard about some new treatment for people with
> bone methastases.
[stuff cut]
> My question is: has anyone heard of this treatment, has
> experience with this treatment or knows where it is used ?
> Thanks,
> Hans Arts
> han…@euronet.nl
The name you want to look under for references about this is Øystein
Fodstad (the first letter of the first name is O with a / through it) at
the Institute for Cancer Research at the Norwegian Radium Hospital, Oslo,
Norway. They have done alot of work in this area some of which resulted in
the formation of Dynal, the company that makes the paramagnetic beads.
———————————————————————
"To someone with a hammer, many things
look like nails that need banging in"
Pearse Ward
wa…@herald.usask.ca
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In Article <3mcvkn$…@news.euro.net>, Hans Arts <han…@euronet.nl> wrote:
- Hide quoted text — Show quoted text -
>Recently I heard about some new treatment for people with
>bone methastases.
>I will try to describe it.
>The first step is to take bone marrow of the patient.
>Then a suspension of very small plastic globulus is added
>to the bone marrow. These globulus are coated with monoclonal
>antibodies. They also contain iron molecules.
>What happens is that they will surround the cancer cells in
>the solution. Then a strong magnetic field is applied to the
>solution so that the cancer cells are pulled out of the solution.
>In this way it is possible to obtain a very good
>separation between cancer and normal cells. It should be
>possible to remove 1 cancer cell from 1.000.000 normal cells.
>After intensive chemotherapy the patients own (filtered) bone
>marrow can be put back.
>My question is: has anyone heard of this treatment, has
>experience with this treatment or knows where it is used ?
Well, that sounds like a variation of the technique called "autologous
bone marrow transplant." The versions I’ve heard of used complement
(proteins which destroy cells which have bound antibodies) to kill of any
cancer cells, rather than "Magnabeads" (as they’re called in the research
lab, where they’ve been used for that sort of thing fo years).
There are two general problems with this approach:
1. What if some tumor cells don’t have the antigen you tagged?
2. What if the high level chemo/radiotherapy _doesn’t_ kill off all of
the tumor in the patient?
Those may or may not be insurmountable problems, but they’ve been in
trials for over a decade (my mom had one for multiple myeloma in 1986).
-J
________________________________________________________________________________
J Thompson je…@columbia.edu
Class of 1997, Columbia University P&S (a.k.a. Columbia Med)
If I say anything incomprehensible, translations to usable English
are provided by e-mail… Free of charge!
I believe in courtesy copies of posts by e-mail
Yes, three of my friends have had this done very successfully. For one
man, it was his third bone marrow transplant. I am not sure if the cancer
cells were removed magnetically but, somehow, the stem cells they removed
were cleaned somehow before thet were replaced back into the body. If you
want more info, I will see what I can get for you. In the meantime, I
will ask them a litle more about their transplants.
Darlene
- Hide quoted text — Show quoted text -
> My question is: has anyone heard of this treatment, has
> experience with this treatment or knows where it is used ?
> Thanks,
> Hans Arts
> han…@euronet.nl
The treatment of ex vivo bone marrow with monoclonal antibodies and
magnetic beads is commonly used in preparation for autologous bone marrow
transplants in children with stage D neuroblastoma. Drawbacks to the
procedure include (1) failure to achieve good control of the tumor outside
of the bone marrow prior to transplantation, and (2) inadequate purging so
that residual tumor cells are "reimplanted" with the transplant. The
Pediatric Oncology Group currently has trials underway to investigate
whether this form of high dose therapy with autologous resuce is superior
to standard chemotherapy.
jfo
jfo, peds oncology